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Ptk2tm1.1Jtpa
Targeted Allele Detail
Nomenclature
Symbol: Ptk2tm1.1Jtpa
Name: PTK2 protein tyrosine kinase 2; targeted mutation 1.1, J Thomas Parsons
MGI ID: MGI:3821611
Gene: Ptk2  Location: Chr15:73205102-73423280 bp, - strand  Genetic Position: Chr15, 33.94 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:142495
Parent Cell Line:  IB10/E14IB10 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was inserted upstream of the non-coding LE exon and a floxed neo cassette was inserted downstream of it. Transient cre expression was used to remove the neo cassette and LE exon. The absence of protein expression was confirmed by western blot analysis on lung extracts. (J:142495)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ptk2 Mutation:  70 strains or lines available
References
Original:  J:142495 Hayasaka H, et al., Disruption of FRNK expression by gene targeting of the intronic promoter within the focal adhesion kinase gene. J Cell Biochem. 2007 Nov 1;102(4):947-54
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory