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Glrxtm3Ysh
Targeted Allele Detail
Nomenclature
Symbol: Glrxtm3Ysh
Name: glutaredoxin; targeted mutation 3, Ye-Shih Ho
MGI ID: MGI:3820704
Synonyms: TTase-
Gene: Glrx  Location: Chr13:75839885-75850151 bp, + strand  Genetic Position: Chr13, 40.95 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141903
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 as well as parts of intron 1 and intron 2 were replaced with a neomycin resistance cassette. No full sized protein is seen in homozygotes although a smaller sized mRNA band is detected. (J:141903)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Glrx Mutation:  2 strains or lines available
References
Original:  J:141903 Lofgren S, et al., Effect of thioltransferase (glutaredoxin) deletion on cellular sensitivity to oxidative stress and cell proliferation in lens epithelial cells of thioltransferase knockout mouse. Invest Ophthalmol Vis Sci. 2008 Oct;49(10):4497-505
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/07/2020
MGI 6.15
The Jackson Laboratory