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Mylktm1Mzhu
Targeted Allele Detail
Nomenclature
Symbol: Mylktm1Mzhu
Name: myosin, light polypeptide kinase; targeted mutation 1, Min-Sheng Zhu
MGI ID: MGI:3820656
Synonyms: Mlckflox, Mylktm1Mzhv
Gene: Mylk  Location: Chr16:34745210-35002420 bp, + strand  Genetic Position: Chr16, 24.49 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141907
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsAn frt flanked neo selection cassette was inserted in intron 25 just upstream of a loxP site. A second loxP site was placed in intron 22. (J:141907)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 12 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mylk Mutation:  5 strains or lines available
References
Original:  J:141907 He WQ, et al., Myosin light chain kinase is central to smooth muscle contraction and required for gastrointestinal motility in mice. Gastroenterology. 2008 Aug;135(2):610-20
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory