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Cnn2tm1.2Jin
Targeted Allele Detail
Nomenclature
Symbol: Cnn2tm1.2Jin
Name: calponin 2; targeted mutation 1.2, Jian-Ping Jin
MGI ID: MGI:3820423
Gene: Cnn2  Location: Chr10:79988600-79995400 bp, + strand  Genetic Position: Chr10, 39.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141867
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsLoxP sites were inserted in introns 1 and 2 an an frt flanked neomycin resistance cassette was inserted downstream of the loxP site in intron 2. Mice were then crossed to Gt(ROSA)26Sor to produce mice with germline deletion of the frt flanked neomycin resistance cassette. These floxed mice (Cnn2tm1.1Jin) were then crossed with Tg(Zp3-cre)93Knw mice. Cre expression results in the germline excision of exon 2. These mice produce no protein product. (J:141867)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cnn2 Mutation:  0 strains or lines available
References
Original:  J:141867 Huang QQ, et al., Role of H2-calponin in regulating macrophage motility and phagocytosis. J Biol Chem. 2008 Sep 19;283(38):25887-99
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory