Bnip3l^tm1.1Gwd
Targeted Allele Detail

Summary

• Symbol: Bnip3l^tm1.1Gwd
• Name: BCL2/adenovirus E1B interacting protein 3-like; targeted mutation 1.1, Gerald W Dorn
• MGI ID: MGI:3819954
• Synonyms: Nix^-
• Gene: Bnip3l Location: Chr14:67222688-67246326 bp, - strand Genetic Position: Chr14, 34.6 cM
• Alliance: Bnip3l^tm1.1Gwd page

Hypomorphism and splenomegaly of wild-type and Bnip3l^tm1.1Gwd/Bnip3l^tm1.1Gwd mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141583
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site and an frt flanked neo resistance cassette were inserted in intron 3. At the same time, an additional loxP site was inserted in intron 6a. Correctly targeted mice were crossed to Gt(ROSA)26Sor mice to excise the selection cassette. These mice were then bred to an unspecified EIIa-cre transgenic mouse to delete exons 4 through 6a. Immunoblot analysis confirmed the absence of protein product. (J:141583)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bnip3l Mutation: 40 strains or lines available

References

• Original: J:141583 Diwan A, et al., Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6794-9
• All: 6 reference(s)