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Postntm1Jmol
Targeted Allele Detail
Nomenclature
Symbol: Postntm1Jmol
Name: periostin, osteoblast specific factor; targeted mutation 1, Jeffery D Molkentin
MGI ID: MGI:3819350
Synonyms: Pn-
Gene: Postn  Location: Chr3:54361109-54391037 bp, + strand  Genetic Position: Chr3, 25.46 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140301
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 4 through 10 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on P1 developing foot and heart extracts. (J:140301)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Postn Mutation:  4 strains or lines available
References
Original:  J:140301 Oka T, et al., Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 3;101(3):313-21
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory