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Targeted Allele Detail
Symbol: Airetm2Mmat
Name: autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy); targeted mutation 2, Mitsuru Matsumoto
MGI ID: MGI:3818933
Synonyms: Airegfp
Gene: Aire  Location: Chr10:78030022-78043610 bp, - strand  Genetic Position: Chr10, 39.72 cM
Germline Transmission:  Earliest citation of germline transmission: J:141379
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsGenomic sequence from immediately after the Kozak sequence in exon 1 to the exon 2 was replaced with GFP and a floxed neo cassette via homologous recombination. The neo cassette was removed via in vivo Cre mediated recombination. Immunohistochemical analysis in heterozygous mice indicates that the pattern of GFP expression is similar to the pattern of endogenous gene expression. (J:141379)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Aire Mutation:  20 strains or lines available
Original:  J:141379 Yano M, et al., Aire controls the differentiation program of thymic epithelial cells in the medulla for the establishment of self-tolerance. J Exp Med. 2008 Nov 24;205(12):2827-38
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory