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Txniptm1.1Rlee
Targeted Allele Detail
Nomenclature
Symbol: Txniptm1.1Rlee
Name: thioredoxin interacting protein; targeted mutation 1.1, Richard T Lee
MGI ID: MGI:3818744
Synonyms: Txnipnull
Gene: Txnip  Location: Chr3:96557957-96561883 bp, + strand  Genetic Position: Chr3, 41.93 cM, cytoband F2.2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141487
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was deleted via cre mediated recombination, Northern and western blot analysis confirmed the absence of mRNA and protein expression in the heart. (J:141487)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Txnip Mutation:  34 strains or lines available
References
Original:  J:141487 Yoshioka J, et al., Targeted deletion of thioredoxin-interacting protein regulates cardiac dysfunction in response to pressure overload. Circ Res. 2007 Dec 7;101(12):1328-38
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory