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Rhcgtm1Ibmm
Targeted Allele Detail
Nomenclature
Symbol: Rhcgtm1Ibmm
Name: Rhesus blood group-associated C glycoprotein; targeted mutation 1, Claude Szpirer
MGI ID: MGI:3818662
Gene: Rhcg  Location: Chr7:79593363-79617657 bp, - strand  Genetic Position: Chr7, 45.09 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141372
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsAn IRES-lacZ gene and a floxed neomycin resistance cassette replaced part of exon 3, exons 4-8, and part of exon 9. Founder mice were crossed with a cre-transgenic strain to removed the neomycin cassette. Gene inactivation was confirmed immunoblotting of male genital tract lysates from homozygous mice (J:141372)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rhcg Mutation:  8 strains or lines available
References
Original:  J:141372 Biver S, et al., A role for Rhesus factor Rhcg in renal ammonium excretion and male fertility. Nature. 2008 Nov 20;456(7220):339-43
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory