About   Help   FAQ
The MGI survey is now closed.
Thanks for your support!
Targeted Allele Detail
Symbol: Strctm1Ugds
Name: stereocilin; targeted mutation 1, Unite de Genetique des Deficits Sensoriels
MGI ID: MGI:3818633
Gene: Strc  Location: Chr2:121363728-121387168 bp, - strand  Genetic Position: Chr2, 60.37 cM
Germline Transmission:  Earliest citation of germline transmission: J:141421
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site was inserted upstream of exon 2 and a floxed hygro cassette was inserted downstream of exon 3. Germ line, cre mediated recombination was used to remove exon 2, exon 3 and the selection cassette. The absence of protein expression was confirmed by immunohistochemistry on P14 cochlear sensory epithelia. (J:141421)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Strc Mutation:  1 strain or line available
Original:  J:141421 Verpy E, et al., Stereocilin-deficient mice reveal the origin of cochlear waveform distortions. Nature. 2008 Nov 13;456(7219):255-8
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 5.21
The Jackson Laboratory