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Tgfbr3tm1.1Jba
Targeted Allele Detail
Nomenclature
Symbol: Tgfbr3tm1.1Jba
Name: transforming growth factor, beta receptor III; targeted mutation 1.1, Joey V Barnett
MGI ID: MGI:3818438
Gene: Tgfbr3  Location: Chr5:107106570-107289629 bp, - strand  Genetic Position: Chr5, 51.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141344
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 of this locus encodes the N terminus, including a portion of the extracellular ligand binding domain. A floxed neo-cassette was placed upstream of exon 3 and a single loxP site was placed downstream of exon 3. Mice carrying the targeted mutation in the germline were crossed with cre-transgenic mice to remove exon 3 and the neo-cassette, leaving in its place a single loxP site. Ligand crosslinking with 125I-TGFbeta to embryonic fibroblasts isolated from homozygotes confirms loss of protein expression. (J:141344)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr3 Mutation:  6 strains or lines available
References
Original:  J:141344 Compton LA, et al., Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res. 2007 Oct 12;101(8):784-91
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory