About   Help   FAQ
Tgfbr3tm1.1Jba
Targeted Allele Detail
Nomenclature
Symbol: Tgfbr3tm1.1Jba
Name: transforming growth factor, beta receptor III; targeted mutation 1.1, Joey V Barnett
MGI ID: MGI:3818438
Gene: Tgfbr3  Location: Chr5:107106570-107289629 bp, - strand  Genetic Position: Chr5, 51.9 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141344
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 3 of this locus encodes the N terminus, including a portion of the extracellular ligand binding domain. A floxed neo-cassette was placed upstream of exon 3 and a single loxP site was placed downstream of exon 3. Mice carrying the targeted mutation in the germline were crossed with cre-transgenic mice to remove exon 3 and the neo-cassette, leaving in its place a single loxP site. Ligand crosslinking with 125I-TGFbeta to embryonic fibroblasts isolated from homozygotes confirms loss of protein expression. (J:141344)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tgfbr3 Mutation:  21 strains or lines available
References
Original:  J:141344 Compton LA, et al., Coronary vessel development is dependent on the type III transforming growth factor beta receptor. Circ Res. 2007 Oct 12;101(8):784-91
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/13/2017
MGI 6.10
The Jackson Laboratory