Foxp3^m1Btlr
Chemically induced Allele Detail

Summary

• Symbol: Foxp3^m1Btlr
• Name: forkhead box P3; mutation 1, Bruce Beutler
• MGI ID: MGI:3817855
• Synonyms: crusty
• Gene: Foxp3 Location: ChrX:7445915-7461482 bp, + strand Genetic Position: ChrX, 3.41 cM
• Alliance: Foxp3^m1Btlr page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Beutler Mutagenetix

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This mutation, discovered because of its visible phenotype in two male G3 progeny of an ENU mutagenized male mouse, has been identified as a T-to-A transversion at nucleotide position 1307 of the gene (Genbank Accession NM_054039), in the twelfth of the gene's 13 exons. It is predicted to result in replacement of isoleucine by asparagine at amino acid position 350 of the protein (p.I350N); the protein's expression in mutant mice has not been analyzed. (J:141212)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxp3 Mutation: 55 strains or lines available

References

• Original: J:141212 Pirie E, et al., Record for "crusty", updated November 14, 2008. MGI Direct Data Submission. 2008
• All: 1 reference(s)