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Zbtb7btm1.1Rbo
Targeted Allele Detail
Nomenclature
Symbol: Zbtb7btm1.1Rbo
Name: zinc finger and BTB domain containing 7B; targeted mutation 1.1, Remy Bosselut
MGI ID: MGI:3817628
Synonyms: ThPok-
Gene: Zbtb7b  Location: Chr3:89377644-89394776 bp, - strand  Genetic Position: Chr3, 39.09 cM, cytoband A1-A2
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:141145
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site was placed into a non-conserved, non-coding portion of exon 3 and a loxP- Frt- flanked neo-cassette was placed 212 bp upstream from the transcription initiation site. Mice were crossed with cre-transgenic mice to delete the coding region and the neo cassette from the germline cells. Gene inactivation was confirmed by a lack of protein detected in immunoblot assays of B cell extracts from homozygotes. (J:141145)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zbtb7b Mutation:  19 strains or lines available
References
Original:  J:141145 Wang L, et al., Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4(+) T cells. Nat Immunol. 2008 Oct;9(10):1122-30
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory