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Targeted Allele Detail
Symbol: Mesp2tm12Ysa
Name: mesoderm posterior 2; targeted mutation 12, Yukimo Saga
MGI ID: MGI:3817238
Synonyms: P2EmB1D
Gene: Mesp2  Location: Chr7:79810727-79813431 bp, + strand  Genetic Position: Chr7, 45.18 cM
Germline Transmission:  Earliest citation of germline transmission: J:141112
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Allele Type:    Targeted (Modified regulatory region)
Mutations:    Insertion, Nucleotide substitutions
Mutation detailsTwo Tbx6 binding sites contained within the minimal pre-somitic mesoderm enhancer region upstream of exon 1 were replaced with ones containing mutations at site B and site D. A floxed neo cassette inserted upstream of the enhancer region was removed by germ line, cre mediated recombination. (J:141112)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mesp2 Mutation:  28 strains or lines available
Original:  J:141112 Yasuhiko Y, et al., Functional importance of evolutionally conserved Tbx6 binding sites in the presomitic mesoderm-specific enhancer of Mesp2. Development. 2008 Nov;135(21):3511-9
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory