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Targeted Allele Detail
Symbol: Gpr15tm1.1Litt
Name: G protein-coupled receptor 15; targeted mutation 1.1, Dan R Littman
MGI ID: MGI:3815547
Synonyms: Gpr15gfp
Gene: Gpr15  Location: Chr16:58717433-58719070 bp, - strand  Genetic Position: Chr16, 34.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:199126
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsPart of exon 1 was replaced by GFP and SV40polyA followed by a loxP-flanked neomycin resistance cassette. The neomycin cassette was later removed by Cre treatment. RT-PCR confirmed the absence of transcript expression in the large intestine lamina propria and spleen. (J:199126)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpr15 Mutation:  16 strains or lines available
Original:  J:199126 Kim SV, et al., GPR15-mediated homing controls immune homeostasis in the large intestine mucosa. Science. 2013 Jun 21;340(6139):1456-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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