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Targeted Allele Detail
Symbol: Gt(ROSA)26Sortm1(Crh)Jde
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Jan Deussing
MGI ID: MGI:3815322
Synonyms: CRH-COE, R26flopCrh
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:149207
Parent Cell Line:  TBV2 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence)
Mutation:    Insertion
Gt(ROSA)26Sortm1(Crh)Jde expresses 1 gene
Mutation detailsCoding sequence for murine Crh gene was preceded by a loxP-flanked transcriptional terminator and then was knocked into the Gt(ROSA)26Sor locus. Upon cre recombinase expression and excision of the loxP-stop sequence, the Crh gene is predicted to be expressed. (J:149207)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  534 strains or lines available
Original:  J:149207 Lu A, et al., Conditional mouse mutants highlight mechanisms of corticotropin-releasing hormone effects on stress-coping behavior. Mol Psychiatry. 2008 Nov;13(11):1028-42
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory