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Slc32a1tm1Lowl
Targeted Allele Detail
Nomenclature
Symbol: Slc32a1tm1Lowl
Name: solute carrier family 32 (GABA vesicular transporter), member 1; targeted mutation 1, Bradford B Lowell
MGI ID: MGI:3815083
Synonyms: Vgatflox, Viaat-lx-lx
Gene: Slc32a1  Location: Chr2:158610767-158615748 bp, + strand  Genetic Position: Chr2, 78.72 cM, cytoband H1-3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140858
Parent Cell Line:  W4 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were inserted flanking exon 2 and an frt flanked kan/neo cassette was inserted via homologous recombination. The kan/neo cassette was subsequently removed via in vivo Flp mediated recombination. (J:140858)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 1 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc32a1 Mutation:  14 strains or lines available
References
Original:  J:140858 Tong Q, et al., Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance. Nat Neurosci. 2008 Sep;11(9):998-1000
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/05/2019
MGI 6.14
The Jackson Laboratory