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Tg(MT1A-Dyrk1a)#Xest
Transgene Detail
Nomenclature
Symbol: Tg(MT1A-Dyrk1a)#Xest
Name: transgene insertion #, Xavier Estivill
MGI ID: MGI:3814575
Synonyms: TgDyrk1A
Transgene: Tg(MT1A-Dyrk1a)#Xest  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6 x SJL
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(MT1A-Dyrk1a)#Xest expresses 1 gene
 
Mutation detailsThe sheep promoter was used to drive expression of the full-length rat gene in the brain, heart and liver. Four lines were created (lines 9, 28, 31 and 33) that carry 2 to 20 copies of the transgene (2, 2, 20 and 5 copies, respectively). The pound symbol used when no line is specified and/or lines are pooled. (J:71821)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:71821 Altafaj X, et al., Neurodevelopmental delay, motor abnormalities and cognitive deficits in transgenic mice overexpressing Dyrk1A (minibrain), a murine model of Down's syndrome. Hum Mol Genet. 2001 Sep 1;10(18):1915-23
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/13/2015
MGI 5.21
The Jackson Laboratory