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Trpa1tm2Kykw
Targeted Allele Detail
Nomenclature
Symbol: Trpa1tm2Kykw
Name: transient receptor potential cation channel, subfamily A, member 1; targeted mutation 2, Kelvin Y Kwan
MGI ID: MGI:3814427
Synonyms: Trpa1 CKO
Gene: Trpa1  Location: Chr1:14942872-14989086 bp, - strand  Genetic Position: Chr1, 4.5 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:169738
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsLoxP sites were placed on either side of exons 22-24 (encoding the S5/S6 transmembrane domains) and an FRT-flanked neomycin resistance cassette inserted in the opposite transcriptional orientation in intron 24. The neomycin cassette was excised by crossing these mice to a Gt(ROSA)26Sor-driven Flp strain on a 129S4/SvJaeSor. (J:169738)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Trpa1 Mutation:  67 strains or lines available
References
Original:  J:169738 Corey D, et al., Generation of a conditional allele of Trpa1. MGI Direct Data Submission. 2011;
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory