Tab1^tm1Mis
Targeted Allele Detail

Summary

• Symbol: Tab1^tm1Mis
• Name: TGF-beta activated kinase 1/MAP3K7 binding protein 1; targeted mutation 1, Yuji Mishina
• MGI ID: MGI:3814196
• Synonyms: Tab1^fx
• Gene: Tab1 Location: Chr15:80017333-80045908 bp, + strand Genetic Position: Chr15, 37.85 cM, cytoband E2
• Alliance: Tab1^tm1Mis page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140317
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: An frt flanked neo cassette with a 5' loxP site was inserted upstream of exon 9 and an additional loxP site was inserted downtream of exon 10. Germ line, flp mediated recombination was used to remove the neo cassette leaving exons 9 and 10 floxed. This allele is hypomorphic as confirmed by phenotypic observations and western blot analysis on E16.5 brain extracts and newborn keratinocytes. (J:140317)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tab1 Mutation: 90 strains or lines available

References

• Original: J:140317 Inagaki M, et al., Generation of a conditional mutant allele for Tab1 in mouse. Genesis. 2008 Aug;46(8):431-9
• All: 6 reference(s)