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Ednrbtm1Nrd
Targeted Allele Detail
Nomenclature
Symbol: Ednrbtm1Nrd
Name: endothelin receptor type B; targeted mutation 1, Noah Druckenbrod
MGI ID: MGI:3813973
Synonyms: Ednrbflex3
Gene: Ednrb  Location: Chr14:103814625-103844173 bp, - strand  Genetic Position: Chr14, 53.05 cM
Evidence of inflammation in both the proximal and mid-colon of the Ednrbtm1Nrd/Ednrbtm1Nrd Gt(ROSA)26Sortm14(CAG-tdTomato)Hze/Gt(ROSA)26Sor+ Tg(Wnt1-cre)11Rth/0 animals

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140320
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed neo cassette was placed upstream of exon 3 and an additional loxP site was inserted downstream of exon 3. (J:140320)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ednrb Mutation:  74 strains or lines available
References
Original:  J:140320 Druckenbrod NR, et al., Targeting of endothelin receptor-B to the neural crest. Genesis. 2008 Aug;46(8):396-400
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory