Apln^tm1Pngr
Targeted Allele Detail

Summary

• Symbol: Apln^tm1Pngr
• Name: apelin; targeted mutation 1, Josef M Penninger
• MGI ID: MGI:3813940
• Gene: Apln Location: ChrX:47114023-47123730 bp, - strand Genetic Position: ChrX, 25.48 cM, cytoband A3.2
• Alliance: Apln^tm1Pngr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140286
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 2 and 3 were replaced with a self-excising ACN-neo cassette. Cre mediated excision occurred in the testes. RT-PCR and western blot analysis confirmed the absence of mRNA and protein expression in the hearts of hemizygous male mice. (J:140286)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Apln Mutation: 13 strains or lines available

Notes

ES cell line = CMT-I (authors state the strain of origin is 129/Ola).

References

• Original: J:140286 Kuba K, et al., Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload. Circ Res. 2007 Aug 17;101(4):e32-42
• All: 12 reference(s)