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Transgene Detail
Symbol: Tg(DBH-PTS)6Csic
Name: transgene insertion 6, Chiho Sumi-Ichinose
MGI ID: MGI:3813870
Synonyms: DPS, DPS-Pts
Transgene: Tg(DBH-PTS)6Csic  Location: unknown  
Strain of Origin:  C57BL/6J
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Tg(DBH-PTS)6Csic expresses 1 gene
Mutation detailsThis transgene consists of a 5.8 kb fragment containing the 5' promoter region of the human DBH gene, a rabbit beta-globin intron, a Kozak sequence, and a 441 bp cDNA encoding the human PTS gene. Five independent lines were generated. Line 6 was selected for further study. This line carries about 400 copies of the transgene. High levels of PTS activity are detected in the adrenal glands and olfactory bulbs while lower levels are found in other brain regions and the liver. (J:102278)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:102278 Sumi-Ichinose C, et al., Genetically rescued tetrahydrobiopterin-depleted mice survive with hyperphenylalaninemia and region-specific monoaminergic abnormalities. J Neurochem. 2005 Nov;95(3):703-14
All:  3 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory