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Tg(SV40-Igh-64C8)H3Hon
Transgene Detail
Nomenclature
Symbol: Tg(SV40-Igh-64C8)H3Hon
Name: transgene insertion H3, Tasuku Honjo
MGI ID: MGI:3813628
Synonyms: H3
Transgene: Tg(SV40-Igh-64C8)H3Hon  Location: unknown  
Transgene
origin
Strain of Origin:  C57BL/6
Transgene
description
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
 
Tg(SV40-Igh-64C8)H3Hon expresses 1 gene
 
Mutation detailsThis transgene consists of a 1.3 kb fragment containing promoter and initiation sequence from SV40, a 0.4 kb cDNA fragment encoding the immunoglobulin heavy chain from the 4C8 hybridoma, a 1.8 kb fragment containing Igh-J3 and Igh-J4 and enhancer sequences, and a 12 kb fragment containing the major intron and Igh-6 from the genomic clones Ch-M-Ig-mu-18 and lambda gtWES-IgH714, respectively. The 4C8 hybridoma contains immunoglobulin genes that encode an anti-murine erythrocyte autoantibody. Seven lines were generated, this a representative record for all lines. The H3 line carries about 10 copies of the transgene on an autosome. RNase protection analysis confirmed expression of the transgene in lymphoid tissues. (J:139864)
Phenotypes
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Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
References
Original:  J:139864 Okamoto M, et al., A transgenic model of autoimmune hemolytic anemia. J Exp Med. 1992 Jan 1;175(1):71-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/20/2015
MGI 5.21
The Jackson Laboratory