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Targeted Allele Detail
Symbol: Synctm1.1Ked
Name: syncoilin; targeted mutation 1.1, Kay E Davies
MGI ID: MGI:3813569
Gene: Sync  Location: Chr4:129287617-129308559 bp, + strand  Genetic Position: Chr4, 63.26 cM
Germline Transmission:  Earliest citation of germline transmission: J:138552
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA loxP site and an frt flanked neomycin selection cassette were inserted in intron 1 and a second loxP site was placed in intron 2. Chimeric mice were bred to a proprietary CMV-cre mouse line on a C57BL/6 background developed by GenOway. This resulted in the excision of both the neomycin selection cassette and exon 2. No protein was detectable immunologically in tissues. (J:138552)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sync Mutation:  11 strains or lines available
This targeted mutation was created in "E129/sv" ES cells.
Original:  J:138552 McCullagh KJ, et al., Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse. Mamm Genome. 2008 May;19(5):339-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
The Jackson Laboratory