About   Help   FAQ
Synctm1.1Ked
Targeted Allele Detail
Nomenclature
Symbol: Synctm1.1Ked
Name: syncoilin; targeted mutation 1.1, Kay E Davies
MGI ID: MGI:3813569
Gene: Sync  Location: Chr4:129287617-129308559 bp, + strand  Genetic Position: Chr4, 63.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138552
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA loxP site and an frt flanked neomycin selection cassette were inserted in intron 1 and a second loxP site was placed in intron 2. Chimeric mice were bred to a proprietary CMV-cre mouse line on a C57BL/6 background developed by GenOway. This resulted in the excision of both the neomycin selection cassette and exon 2. No protein was detectable immunologically in tissues. (J:138552)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Sync Mutation:  11 strains or lines available
Notes
This targeted mutation was created in "E129/sv" ES cells.
References
Original:  J:138552 McCullagh KJ, et al., Analysis of skeletal muscle function in the C57BL6/SV129 syncoilin knockout mouse. Mamm Genome. 2008 May;19(5):339-51
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/17/2017
MGI 6.10
The Jackson Laboratory