Nphp1^tm1Hung
Targeted Allele Detail

Summary

• Symbol: Nphp1^tm1Hung
• Name: nephronophthisis 1 (juvenile) homolog (human); targeted mutation 1, Hung Li
• MGI ID: MGI:3813271
• Synonyms: Nphp1^lox20
• Gene: Nphp1 Location: Chr2:127582652-127630817 bp, - strand Genetic Position: Chr2, 62.09 cM, cytoband F3
• Alliance: Nphp1^tm1Hung page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:140205
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 20 and loxP-flanked neomycin cassette was inserted downstream of exon 20. Correct targeting was confirmed by genomic PCR. The floxed exon contains the polyadenylation signals so that upon expression of cre recombinase, the resulting transcipts derived from this locus would be truncated and have a shorter half-life. (J:140205)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nphp1 Mutation: 26 strains or lines available

References

• Original: J:140205 Jiang ST, et al., Targeted disruption of Nphp1 causes male infertility due to defects in the later steps of sperm morphogenesis in mice. Hum Mol Genet. 2008 Nov 1;17(21):3368-79
• All: 1 reference(s)