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Selenomtm1(KOMP)Vlcg
Targeted Allele Detail
Nomenclature
Symbol: Selenomtm1(KOMP)Vlcg
Name: selenoprotein M; targeted mutation 1, Velocigene
MGI ID: MGI:3812975
Synonyms: Selmtm1Vlcg
Gene: Selenom  Location: Chr11:3514684-3517351 bp, + strand  Genetic Position: Chr11, 2.47 cM, cytoband A1
Mutation
origin
Mutant Cell Lines:  11537A-A8, 11537A-B11, 11537A-E9, 11537A-F5, 11537A-F9, 11537A-H3
Germline Transmission:  Earliest citation of germline transmission: J:203545
Parent Cell Line:  VGB6 (ES Cell)
Strain of Origin:  C57BL/6NTac
Project Collection: KOMP-Regeneron
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion     Vector: ZEN-Ub1
 
Mutation detailsThe insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 2235bp between positions 3414933-3417167 of Chromosome 11 (Genome Build37). The lacZ and floxed neomycin resistance cassette replaced the coding sequence. Western blot analysis confirmed the absence of protein expression in the brain. (J:136110, J:203545)
Generation of the Selenomtm1(KOMP)Vlcg allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 1 line available
Carrying any Selenom Mutation:  9 strains or lines available
Notes
Cell line 11537A-H3 was successfully used to make chimeric mice. Germline transmission was accomplished. J:203545
References
Original:  J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008;
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/26/2020
MGI 6.15
The Jackson Laboratory