Pmp2^{tm1(KOMP)Vlcg}
Targeted Allele Detail

Summary

• Symbol: Pmp2^{tm1(KOMP)Vlcg}
• Name: peripheral myelin protein 2; targeted mutation 1, Velocigene
• MGI ID: MGI:3812759
• Synonyms: Pmp2^{neodeltaEx1-4}, Pmp2^tm1Vlcg
• Gene: Pmp2 Location: Chr3:10244911-10248945 bp, - strand Genetic Position: Chr3, 2.54 cM
• Alliance: Pmp2^{tm1(KOMP)Vlcg} page
• IMPC: Pmp2 gene page

Mutation origin

• Mutant Cell Lines: 10878A-E1, 10878A-E2, 10878B-D5, 10878B-D12, 10878B-G8
• Germline Transmission: Earliest citation of germline transmission: J:204812
• Parent Cell Line: VGB6 (ES Cell)
• Strain of Origin: C57BL/6NTac
• Project Collection: KOMP-Regeneron

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion Vector: ZEN-Ub1
• Mutation details: The insertion of Velocigene cassette ZEN-Ub1 created a deletion of size 3091bp between positions 10245786-10248876 of Chromosome 3 (Build GRCm39). Exons 1-4 were replaced by a lacZ sequence (in frame after the original ATG) and a loxP-neo-loxP cassette. (J:136110, J:211344)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 1 line available
• Carrying any Pmp2 Mutation: 13 strains or lines available

References

• Original: J:136110 Velocigene, Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals). MGI Direct Data Submission. 2008
• All: 4 reference(s)