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Targeted Allele Detail
Symbol: Cxadrtm1Mgot
Name: coxsackie virus and adenovirus receptor; targeted mutation 1, Michael Gotthardt
MGI ID: MGI:3812340
Synonyms: CARrecf
Gene: Cxadr  Location: Chr16:78301496-78359785 bp, + strand  Genetic Position: Chr16, 45.28 cM, cytoband C
Germline Transmission:  Earliest citation of germline transmission: J:140109
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsExon 1, which contains the translation start, was replaced with a floxed exon 1 and an upstream FRT-flanked neomycin resistance cassette. The neomycin resistance cassette was removed by germline expression of the FLP recombinase after targeting. Upon expression of cre recombinase, exon 1 is excised creating a null allele. (J:140109)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cxadr Mutation:  6 strains or lines available
Original:  J:140109 Lisewski U, et al., The tight junction protein CAR regulates cardiac conduction and cell-cell communication. J Exp Med. 2008 Sep 29;205(10):2369-79
All:  1 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory