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Sirt1tm1.1Cxd
Targeted Allele Detail
Nomenclature
Symbol: Sirt1tm1.1Cxd
Name: sirtuin 1; targeted mutation 1.1, Chu-Xia Deng
MGI ID: MGI:3812143
Synonyms: Sirt1-
Gene: Sirt1  Location: Chr10:63319005-63381704 bp, - strand  Genetic Position: Chr10, 32.57 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140089
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsGerm line, cre mediated recombination was used to remove the neo cassette and exons 5 and 6. The absence of protein expression was confirmed by western blot analysis on embryo extracts. (J:140089)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sirt1 Mutation:  56 strains or lines available
References
Original:  J:140089 Wang RH, et al., Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008 Oct 7;14(4):312-23
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory