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Mir223tm1Fcam
Targeted Allele Detail
Nomenclature
Symbol: Mir223tm1Fcam
Name: microRNA 223; targeted mutation 1, Fernando D Camargo
MGI ID: MGI:3811186
Synonyms: miR-223-
Gene: Mir223  Location: ChrX:96242817-96242926 bp, + strand  Genetic Position: ChrX, 42.69 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:140009
Parent Cell Line:  v6.5 (ES Cell)
Strain of Origin:  (C57BL/6 x 129S4/SvJae)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsThe entire 110 bp locus was replaced by a neomycin resistance cassette. Northern blot analysis of granulocyte RNA from hemizygous mice revealed a complete absence of locus expression. (J:140009)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mir223 Mutation:  3 strains or lines available
References
Original:  J:140009 Johnnidis JB, et al., Regulation of progenitor cell proliferation and granulocyte function by microRNA-223. Nature. 2008 Feb 28;451(7182):1125-9
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory