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Targeted Allele Detail
Symbol: Itm2btm1Ldad
Name: integral membrane protein 2B; targeted mutation 1, Luciano D'Adamio
MGI ID: MGI:3810986
Gene: Itm2b  Location: Chr14:73599666-73622729 bp, - strand  Genetic Position: Chr14, 38.88 cM
Germline Transmission:  Earliest citation of germline transmission: J:138796
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA loxP site was inserted 200 bp 5' of exon 2 and a floxed PGK-neo cassette was inserted in intron 2 via homologous recombination. The floxed PGK-neo cassette was deleted via in vivo Cre-mediated recombination, leaving exon 2 floxed. (J:138796)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Itm2b Mutation:  12 strains or lines available
Original:  J:138796 Matsuda S, et al., BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci. 2008 Aug 27;28(35):8668-76
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory