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Targeted Allele Detail
Symbol: Men1tm2.1Gfk
Name: multiple endocrine neoplasia 1; targeted mutation 2.1, Graham F Kay
MGI ID: MGI:3810641
Synonyms: second line
Gene: Men1  Location: Chr19:6334979-6340891 bp, + strand  Genetic Position: Chr19, 4.45 cM, cytoband A
Germline Transmission:  Earliest citation of germline transmission: J:116086
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129T2/SvEms
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsFloxed sequence including exon 2 and a neomycin cassette was excised from the gene by the expression of cre recombinase. Exon 2 contained the initiator methionine and 400 bp of coding sequence. Western blot analysis showed an absence of encoded protein in homozygous mutant embryos. (J:75116)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Men1 Mutation:  17 strains or lines available
Original:  J:116086 Loffler KA, et al., Broad tumor spectrum in a mouse model of multiple endocrine neoplasia type 1. Int J Cancer. 2007 Jan 15;120(2):259-67
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory