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Transgene Detail
Symbol: Tg(tetO-Kdr*)4377.5Rwng
Name: transgene insertion 4377.5, Rong Wang
MGI ID: MGI:3810550
Synonyms: TRE-VEGFR2T
Transgene: Tg(tetO-Kdr*)4377.5Rwng  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence)
Mutation:    Insertion
Tg(tetO-Kdr*)4377.5Rwng expresses 1 gene
Mutation detailsThe transgene construct was designed with a truncated mouse Kdr (kinase insert domain protein receptor) gene, under the control of heptamerized tetracycline operator (tetO; also called tetracycline-responsive element (TRE) or tet-operator) sequences and a cytomegalovirus minimal promoter with a beta-globin poly A signal. The truncated gene encodes amino acids 1 through 828, which includes the cytoplasmic tyrosine kinase domain, and has a hemaglutin (HA) tag fused at the C terminus.This transgene was injected into fertilized FVB/N mouse eggs. Founder line 4377.5 was subsequently established. (J:100427)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:100427 Carpenter B, et al., VEGF is crucial for the hepatic vascular development required for lipoprotein uptake. Development. 2005 Jul;132(14):3293-303
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory