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Tshz3tm1Lafa
Targeted Allele Detail
Nomenclature
Symbol: Tshz3tm1Lafa
Name: teashirt zinc finger family member 3; targeted mutation 1, Laurent Fasano
MGI ID: MGI:3810527
Synonyms: Tshz3lacZ
Gene: Tshz3  Location: Chr7:36698118-36773553 bp, + strand  Genetic Position: Chr7, 22.79 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138769
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsMost of exon 2 was replaced with a lacZ and neo cassette. The absence of protein expression was confirmed by immunohistochemistry on E15.5 ureters. (J:138769)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tshz3 Mutation:  28 strains or lines available
References
Original:  J:138769 Caubit X, et al., Teashirt 3 is necessary for ureteral smooth muscle differentiation downstream of SHH and BMP4. Development. 2008 Oct;135(19):3301-10
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/12/2019
MGI 6.14
The Jackson Laboratory