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Orai1tm1Rao
Targeted Allele Detail
Nomenclature
Symbol: Orai1tm1Rao
Name: ORAI calcium release-activated calcium modulator 1; targeted mutation 1, Anjana Rao
MGI ID: MGI:3810487
Gene: Orai1  Location: Chr5:123153137-123168519 bp, + strand  Genetic Position: Chr5, 62.72 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139730
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  C57BL/6NTac
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsExon 1 was replaced with a self-deleting neomycin cassette that was excised in the germ line of male mice carrying the targeted allele. Gene inactivation was confirmed by a lack mRNA transcript in CD4+ T cells and B cells. No protein expression was detected in the skin by immunohistochemical analysis. (J:139730)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Orai1 Mutation:  27 strains or lines available
Notes
ES cell line = B6/3.
References
Original:  J:139730 Gwack Y, et al., Hair loss and defective T- and B-cell function in mice lacking ORAI1. Mol Cell Biol. 2008 Sep;28(17):5209-22
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/16/2021
MGI 6.17
The Jackson Laboratory