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Del(7Or2h1-Rr320)1Mkg
Targeted Allele Detail
Summary
Symbol: Del(7Or2h1-Rr320)1Mkg
Name: deletion, Chr 7, Mark Groudine 1
MGI ID: MGI:3810287
Synonyms: Del(7Olfr64-Hbb-ar)1Mkg, Del(7Or2h1-Hbb-ar)1Mkg, deltaHS-62.5-deltaLCR
Gene: Del(7Or2h1-Rr320)1Mkg  Location: unknown  Genetic Position: Chr7, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139198
Parent Cell Line:  BK4 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Intergenic deletion, Intragenic deletion
  Del(7Or2h1-Rr320)1Mkg involves 4 genes/genome features (Rr320, Or51b4, Or51b17 ...) View all
 
Mutation detailsES cells carrying the Rr320tm1.1Mkg allele, which has most of the Rr320 (Hbb-ar) region replaced with a loxP site, were targeted in cis with a construct that replaced the upstream HS-62.5 element with a loxP site flanked neomycin selection cassette. This substitution removed nucleotides -63238 through -59669, relative to the start site of the Hbb-y gene. Transient expression of Cre recombinase eliminated the entire genomic sequence between the newly inserted floxed neo cassette and the loxP site present from the Rr320rtm1.1Mkg allele. This deletion removes genes Olfr64, Olf65, Olf66, and almost all of the Hbb-ar region. (J:139198)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Del(7Or2h1-Rr320)1Mkg Mutation:  0 strains or lines available
Notes
Male ES cells, deltaLCR-D/S-1, were generated from male mice on a 129 background that were heterozygous for the Hbb-artm1.1Mkg allele, carried two different variants of the Hbb genes (HbbD/HbbS) and were hemizygous for the null Hprtb-m3 allele.
References
Original:  J:139198 Bender MA, et al., Flanking HS-62.5 and 3' HS1, and regions upstream of the LCR, are not required for beta-globin transcription. Blood. 2006 Aug 15;108(4):1395-401
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory