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Apobec3Rfv3-s
Spontaneous Allele Detail
Nomenclature
Symbol: Apobec3Rfv3-s
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; recovery from Friend virus 3, susceptible
MGI ID: MGI:3809768
Gene: Apobec3  Location: Chr15:79891659-79915906 bp, + strand  Genetic Position: Chr15, 37.85 cM, cytoband E2
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Spontaneous
Mutation:    Other
 
Mutation detailsThis gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This recessive allele is found in BALB/c, and A.BY strains and is associated with high FV titers after inoculation. This allele produces an alternative mRNA transcript that excludes exon 2 and produces a protein that is 3- to 5- fold less potent in anti-viral activity as the protein encoded by the Apobec3Rfv3-s allele. (J:138778)
Inheritance:    Recessive
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apobec3 Mutation:  115 strains or lines available
References
Original:  J:6147 Doig D, et al., Anti-Friend virus antibody is associated with recovery from viremia and loss of viral leukemia cell-surface antigens in leukemic mice. Identification of Rfv-3 as a gene locus influencing antibody production. J Exp Med. 1979 Jul 1;150(1):10-9
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory