About   Help   FAQ
Apobec3Rfv3-r
Allele Detail
Nomenclature
Symbol: Apobec3Rfv3-r
Name: apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3; recovery from Friend virus 3, resistant
MGI ID: MGI:3809767
Gene: Apobec3  Location: Chr15:79891659-79915906 bp, + strand  Genetic Position: Chr15, 37.85 cM, cytoband E2
Mutation
origin
Strain of Origin:  multiple strains
Mutation
description
Allele Type:    Not Applicable (Not Applicable)
Mutation:    Not Applicable
 
Mutation detailsThis gene locus controls recovery from viremia and leukemia induced by Friend virus (FV). This dominant allele is found in C57BL/6J, C57BL/10, and 129P2/OlaHsd strains and allows for recovery from both viremia and leukemia in H2b mice. Recovery from viremia only is seen in H2a mice. This allele produces a full length mRNA transcript (including exon 2) that encodes for a protein with potent anti-viral activity. (J:138778)
Inheritance:    Dominant
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Apobec3 Mutation:  115 strains or lines available
References
Original:  J:6107 Chesebro B, et al., Identification of a non-H-2 gene (Rfv-3) influencing recovery from viremia and leukemia induced by Friend virus complex. Proc Natl Acad Sci U S A. 1979 Jan;76(1):425-9
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/13/2019
MGI 6.14
The Jackson Laboratory