Tradd^tm1Mak
Targeted Allele Detail

Summary

• Symbol: Tradd^tm1Mak
• Name: TNFRSF1A-associated via death domain; targeted mutation 1, Tak W Mak
• MGI ID: MGI:3809706
• Synonyms: Tradd^flox
• Gene: Tradd Location: Chr8:105985207-105991226 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Tradd^tm1Mak page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138824
• Parent Cell Line: IB10/E14IB10 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, Hypomorph)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP-flanked neo-cassette was inserted downstream of exon 5. This allele is considered a hypomorph since it produces lower amounts of protein than the wild-type allele when found in conjunction with a null allele. (J:138824)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tradd Mutation: 18 strains or lines available

References

• Original: J:138824 Chen NJ, et al., Beyond tumor necrosis factor receptor: TRADD signaling in toll-like receptors. Proc Natl Acad Sci U S A. 2008 Aug 26;105(34):12429-34
• All: 1 reference(s)