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Selplgtm2Rpmc
Targeted Allele Detail
Nomenclature
Symbol: Selplgtm2Rpmc
Name: selectin, platelet (p-selectin) ligand; targeted mutation 2, Rodger P McEver
MGI ID: MGI:3809664
Synonyms: deltaCD
Gene: Selplg  Location: Chr5:113818536-113832644 bp, - strand  Genetic Position: Chr5, 55.59 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138731
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe entire 67 residue cytoplasmic domain was deleted except for the membrane proximal arginine. A codon for a second adjacent arginine followed by two stop codons was inserted. A loxed neo cassette was introduced downstream of exon 2 and sebsequently removed by transient cre expression from properly targeted ES cells. The extracellular domain and the transmembrane domain are expressed normally. (J:138731)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Selplg Mutation:  12 strains or lines available
References
Original:  J:138731 Miner JJ, et al., Separable requirements for cytoplasmic domain of PSGL-1 in leukocyte rolling and signaling under flow. Blood. 2008 Sep 1;112(5):2035-45
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory