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Myd88tm1Defr
Targeted Allele Detail
Nomenclature
Symbol: Myd88tm1Defr
Name: myeloid differentiation primary response gene 88; targeted mutation 1, Anthony L DeFranco
MGI ID: MGI:3809600
Synonyms: Myd88fl
Gene: Myd88  Location: Chr9:119165000-119169084 bp, - strand  Genetic Position: Chr9, 71.33 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139001
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsExon 3 was flanked by loxP sites by placing a FRT-flanked neo-cassette with a 3' loxP site upstream of exon 3 with an additional loxP site being placed downstream of exon 3. Founders were crossed with ACTB-FLPe mice to remove the neo selection cassette. Expression levels of Myd88 were unaffected by loxP insertion. Cre-recombination is predicted to excise exon 3 and create a null allele. (J:139001)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Myd88 Mutation:  43 strains or lines available
References
Original:  J:139001 Hou B, et al., Toll-like Receptors Activate Innate and Adaptive Immunity by using Dendritic Cell-Intrinsic and -Extrinsic Mechanisms. Immunity. 2008 Aug;29(2):272-82
All:  108 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory