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Ano1tm1Bdh
Targeted Allele Detail
Nomenclature
Symbol: Ano1tm1Bdh
Name: anoctamin 1, calcium activated chloride channel; targeted mutation 1, Brian D Harfe
MGI ID: MGI:3809591
Synonyms: TMEM16A-, Tmem16atm1Bdh
Gene: Ano1  Location: Chr7:144588549-144751974 bp, - strand  Genetic Position: Chr7, 88.85 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138613
Parent Cell Line:  CJ7 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 12 was replaced with a neo cassette. This deletion results in a frame shift and a premature stop codon 40 amino acids downstream of the deletion. Seven of the eight transmembrane domains are disrupted due to this frame shift. (J:138613)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ano1 Mutation:  22 strains or lines available
References
Original:  J:138613 Rock JR, et al., The transmembrane protein TMEM16A is required for normal development of the murine trachea. Dev Biol. 2008 Sep 1;321(1):141-9
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory