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Csrp2tm1Rawe
Targeted Allele Detail
Nomenclature
Symbol: Csrp2tm1Rawe
Name: cysteine and glycine-rich protein 2; targeted mutation 1, Ralf Weiskirchen
MGI ID: MGI:3809532
Gene: Csrp2  Location: Chr10:110920176-110939514 bp, + strand  Genetic Position: Chr10, 57.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:138969
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neo cassette was inserted into exon 4 at nucleotide 7292 via homologous recombination. Northern blot and quantitative RT-PCR confirmed a 50% reduction in wild-type transcript and detected an aberrant message consisting of a splicing between exon 3 and the downstream neo cassette/exon 4 boundary in heterozygotes. Western blot analysis of kidney homogenates from homozygotes confirmed the absence of protein. (J:138969)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Csrp2 Mutation:  93 strains or lines available
References
Original:  J:138969 Sagave JF, et al., Targeted disruption of the mouse Csrp2 gene encoding the cysteine- and glycine-rich LIM domain protein CRP2 result in subtle alteration of cardiac ultrastructure. BMC Dev Biol. 2008;8:80
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/16/2017
MGI 6.09
The Jackson Laboratory