Hcn4tm1(cre/ERT2)Anlu
Targeted Allele Detail
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Symbol: |
Hcn4tm1(cre/ERT2)Anlu |
Name: |
hyperpolarization-activated, cyclic nucleotide-gated K+ 4; targeted mutation 1, Andreas Ludwig |
MGI ID: |
MGI:3809312 |
Synonyms: |
HCN4-KiT, HCN4KiT-Cre, Hcn4tm1(cre/ESR1)Anlu |
Gene: |
Hcn4 Location: Chr9:58730695-58770458 bp, + strand Genetic Position: Chr9, 31.8 cM, cytoband C
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Alliance: |
Hcn4tm1(cre/ERT2)Anlu page
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Germline Transmission: |
Earliest citation of germline transmission:
J:139266
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
Not Specified
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Allele Type: |
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Targeted (Inducible, Recombinase) |
Inducer: |
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tamoxifen |
Mutation: |
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Insertion
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Hcn4tm1(cre/ERT2)Anlu expression driven by
1 gene
Knock-in expression driven by:
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Mutation details: A cre/ERT2 fusion gene and a neo cassette were inserted into exon 1 downstream of the translation initiation codon. Expression is tamoxifen inducible and localized to the superior vena cava in the proximity of the right atrial appendage and the aorta, specifically in the sinoatrial and atrioventricular nodes.
(J:139266)
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Activity: |
Tissue activity of this recombinase allele
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Driver:
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Hcn4
(mouse)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hcn4 Mutation: |
67 strains or lines available
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Original: |
J:139266 Hoesl E, et al., Tamoxifen-inducible gene deletion in the cardiac conduction system. J Mol Cell Cardiol. 2008 Jul;45(1):62-9 |
All: |
9 reference(s) |
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