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Sh2d4atm1.1Pdk
Targeted Allele Detail
Nomenclature
Symbol: Sh2d4atm1.1Pdk
Name: SH2 domain containing 4A; targeted mutation 1.1, Philip D King
MGI ID: MGI:3809252
Gene: Sh2d4a  Location: Chr8:68276567-68347694 bp, + strand  Genetic Position: Chr8, 33.76 cM, cytoband C1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:139245
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
 
Mutation detailsSh2d4a homozygotes were crossed with Tg(CMV-cre)1Ipc transgenic mice that express Cre-recombinase in the germline. The loxP-flanked exon 8 of the gene locus was excised creating a null allele. Gene inactivation was confirmed by immunoblotting of splenic tissue. (J:139245)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d4a Mutation:  13 strains or lines available
References
Original:  J:139245 Lapinski PE, et al., Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. J Immunol. 2008 Aug 1;181(3):2019-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory