About   Help   FAQ
Targeted Allele Detail
Symbol: Sh2d4atm1.1Pdk
Name: SH2 domain containing 4A; targeted mutation 1.1, Philip D King
MGI ID: MGI:3809252
Gene: Sh2d4a  Location: Chr8:68276567-68347699 bp, + strand  Genetic Position: Chr8, 33.76 cM, cytoband C1
Germline Transmission:  Earliest citation of germline transmission: J:139245
Parent Cell Line:  Bruce 4 (ES Cell)
Strain of Origin:  B6.Cg-Thy1a
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsSh2d4a homozygotes were crossed with Tg(CMV-cre)1Ipc transgenic mice that express Cre-recombinase in the germline. The loxP-flanked exon 8 of the gene locus was excised creating a null allele. Gene inactivation was confirmed by immunoblotting of splenic tissue. (J:139245)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sh2d4a Mutation:  14 strains or lines available
Original:  J:139245 Lapinski PE, et al., Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. J Immunol. 2008 Aug 1;181(3):2019-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.16
The Jackson Laboratory