Sh2d4a^tm1Pdk
Targeted Allele Detail

Summary

• Symbol: Sh2d4a^tm1Pdk
• Name: SH2 domain containing 4A; targeted mutation 1, Philip D King
• MGI ID: MGI:3809251
• Gene: Sh2d4a Location: Chr8:68729219-68800351 bp, + strand Genetic Position: Chr8, 33.76 cM, cytoband C1
• Alliance: Sh2d4a^tm1Pdk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139245
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted around exon 8 and a frt-flanked neomycin cassette was inserted in the intronic sequence between exons 8 and 9. Progeny were crossed with transgenic mice expressing Flp-recombinase in order to remove the neomycin resistance cassette. (J:139245)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sh2d4a Mutation: 21 strains or lines available

References

• Original: J:139245 Lapinski PE, et al., Genetic analysis of SH2D4A, a novel adapter protein related to T cell-specific adapter and adapter protein in lymphocytes of unknown function, reveals a redundant function in T cells. J Immunol. 2008 Aug 1;181(3):2019-27
• All: 1 reference(s)