Igh-J^{tm3(3H9-VDJ*)Mwg}
Targeted Allele Detail

Nomenclature

• Symbol: Igh-J^{tm3(3H9-VDJ*)Mwg}
• Name: immunoglobulin heavy chain, joining region; targeted mutation 3, Martin Weigert
• MGI ID: MGI:3808989
• Synonyms: 3H9H/56R/76R
• Gene: Igh-J Location: unknown Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:126940
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intergenic deletion
• Mutation details: The endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody with two amin acid substitutions. These substitutions were an arginine for an aspartate at position 56 (A56R) and an arginine for a serine at position 76 (S76R). A neomycin resistance gene was also included upstream of the construct. (J:126940)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh-J Mutation: 14 strains or lines available

References

• Original: J:126940 Li H, et al., Editors and editing of anti-DNA receptors. Immunity. 2001 Dec;15(6):947-57
• All: 2 reference(s)