About   Help   FAQ
Igh-Jtm3(3H9-VDJ*)Mwg
Targeted Allele Detail
Nomenclature
Symbol: Igh-Jtm3(3H9-VDJ*)Mwg
Name: immunoglobulin heavy chain, joining region; targeted mutation 3, Martin Weigert
MGI ID: MGI:3808989
Synonyms: 3H9H/56R/76R
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:126940
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThe endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody with two amin acid substitutions. These substitutions were an arginine for an aspartate at position 56 (A56R) and an arginine for a serine at position 76 (S76R). A neomycin resistance gene was also included upstream of the construct. (J:126940)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
References
Original:  J:126940 Li H, et al., Editors and editing of anti-DNA receptors. Immunity. 2001 Dec;15(6):947-57
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/10/2022
MGI 6.19
The Jackson Laboratory