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Targeted Allele Detail
Symbol: Igh-Jtm3(3H9-VDJ*)Mwg
Name: immunoglobulin heavy chain, joining region; targeted mutation 3, Martin Weigert
MGI ID: MGI:3808989
Synonyms: 3H9H/56R/76R
Gene: Igh-J  Location: unknown  Genetic Position: Chr12, Syntenic
Germline Transmission:  Earliest citation of germline transmission: J:126940
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted
Mutations:    Insertion, Intergenic deletion
Mutation detailsThe endogenous DQ52 and all four heavy chain J elements were replaced by a rearranged heavy chain V 3H9 gene encoding an H chain of anti-dsDNA antibody with two amin acid substitutions. These substitutions were an arginine for an aspartate at position 56 (A56R) and an arginine for a serine at position 76 (S76R). A neomycin resistance gene was also included upstream of the construct. (J:126940)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Igh-J Mutation:  14 strains or lines available
Original:  J:126940 Li H, et al., Editors and editing of anti-DNA receptors. Immunity. 2001 Dec;15(6):947-57
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.19
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