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Targeted Allele Detail
Symbol: Fmr1tm1.1Cidz
Name: fragile X mental retardation syndrome 1; targeted mutation 1., C I De Zeeuw
MGI ID: MGI:3808885
Synonyms: Fmr1 KO2
Gene: Fmr1  Location: ChrX:68678541-68717963 bp, + strand  Genetic Position: ChrX, 34.83 cM
Germline Transmission:  Earliest citation of germline transmission: J:108008
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA germline null mutation was created by crossing Fmr1 mice, which has the first coding exon floxed, with mice that express Cre-recombinase in the germline (Tg(CAG-cre)13Miya). Gene inactivation was confirmed by a lack of protein expression in the brain and testes as determined by immunoblot analysis. (J:108008)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fmr1 Mutation:  22 strains or lines available
Original:  J:108008 Mientjes EJ, et al., The generation of a conditional Fmr1 knock out mouse model to study Fmrp function in vivo. Neurobiol Dis. 2006 Mar;21(3):549-55
All:  11 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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