Tk2^tm1Mihi
Targeted Allele Detail

Summary

• Symbol: Tk2^tm1Mihi
• Name: thymidine kinase 2, mitochondrial; targeted mutation 1, Michio Hirano
• MGI ID: MGI:3808750
• Synonyms: Tk2^mut
• Gene: Tk2 Location: Chr8:104953317-104975190 bp, - strand Genetic Position: Chr8, 53.04 cM
• Alliance: Tk2^tm1Mihi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:139195
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: The coding sequence of exon 5 was modified such that the amino acid asparagine was substituted for histidine at position 126 (H126N). A floxed neo cassette used for selection purposes was removed by cre mediated recombination. (J:139195)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tk2 Mutation: 19 strains or lines available

References

• Original: J:139195 Akman HO, et al., Thymidine kinase 2 (H126N) knockin mice show the essential role of balanced deoxynucleotide pools for mitochondrial DNA maintenance. Hum Mol Genet. 2008 Aug 15;17(16):2433-40
• All: 5 reference(s)